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Michael Janech

Associate Professor, SC Smart State Endowed Chair in Marine Environmental Health

Address: Hollings Marine Lab (HML) A216-C
Phone: 843.460.9788
E-mail: janechmg@cofc.edu



Education

B.S. – Biology, Oakland University

M.S. – Marine Biology, College of Charleston

Ph.D. – Molecular and Cellular Biology, Marine Biomedicine, Medical University of South Carolina

Post-Doc – Université de Montpellier II/IFREMER


Research Interests

Research in my laboratory focuses on mass spectrometry as an analytical tool to study comparative mechanisms underlying physiology and pathophysiology at the level of proteins.  These studies are complemented by the use of proteomics, which is the study of many proteins at one time and their post-translational modifications.  Interests include:  

1) comparative proteomics and metaproteomics,

2) biomarkers of human and marine mammal disease,

3) mechanisms of osmoregulation and kidney function,

4) proteomics of algae.

My laboratory is a lead participant in the NIST COMPARE project: https://www.nist.gov/programs-projects/comparative-mammalian-proteome-aggregator-resource-compare-program, which is a multi-institutional effort to characterize proteome differences between mammals to identify proteins that correlate with unique physiological adaptations.


Publications

Select Publications

Neely, B. A.; Prager, K. C.; Bland, A. M.; Fontaine, C.; Gulland, F. M.; Janech, M. G., Proteomic Analysis of Urine from California Sea Lions ( Zalophus californianus): A Resource for Urinary Biomarker Discovery. J Proteome Res 2018.

Velez, J. C. Q.; Arif, E.; Rodgers, J.; Hicks, M. P.; Arthur, J. M.; Nihalani, D.; Bruner, E. T.; Budisavljevic, M. N.; Atkinson, C.; Fitzgibbon, W. R.; Janech, M. G., Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury. J Am Soc Nephrol 2017, 28 (7), 2119-2132.

Mock, T.; Otillar, R. P.; Strauss, J.; McMullan, M.; Paajanen, P.; Schmutz, J.; Salamov, A.; Sanges, R.; Toseland, A.; Ward, B. J.; Allen, A. E.; Dupont, C. L.; Frickenhaus, S.; Maumus, F.; Veluchamy, A.; Wu, T.; Barry, K. W.; Falciatore, A.; Ferrante, M. I.; Fortunato, A. E.; Glockner, G.; Gruber, A.; Hipkin, R.; Janech, M. G.; Kroth, P. G.; Leese, F.; Lindquist, E. A.; Lyon, B. R.; Martin, J.; Mayer, C.; Parker, M.; Quesneville, H.; Raymond, J. A.; Uhlig, C.; Valas, R. E.; Valentin, K. U.; Worden, A. Z.; Armbrust, E. V.; Clark, M. D.; Bowler, C.; Green, B. R.; Moulton, V.; van Oosterhout, C.; Grigoriev, I. V., Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus. Nature 2017, 541 (7638), 536-540.

Sobolesky, P. M.; Harrell, T. S.; Parry, C.; Venn-Watson, S.; Janech, M. G., Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids. Front Endocrinol (Lausanne) 2016, 7, 33.

Sobolesky, P.; Parry, C.; Boxall, B.; Wells, R.; Venn-Watson, S.; Janech, M. G., Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. Sci Rep 2016, 6, 33879.

Neely, B. A.; Soper, J. L.; Gulland, F. M.; Bell, P. D.; Kindy, M.; Arthur, J. M.; Janech, M. G., Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics 2015, 15 (23-24), 4051-63.

Velez, J. C.; Janech, M. G.; Hicks, M. P.; Morinelli, T. A.; Rodgers, J.; Self, S. E.; Arthur, J. M.; Fitzgibbon, W. R., Lack of renoprotective effect of chronic intravenous angiotensin-(1-7) or angiotensin-(2-10) in a rat model of focal segmental glomerulosclerosis. PLoS One 2014, 9 (10), e110083.

Neely, B. A.; Ferrante, J. A.; Chaves, J. M.; Soper, J. L.; Almeida, J. S.; Arthur, J. M.; Gulland, F. M.; Janech, M. G., Proeomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis. PLoS One 2014, 10 (4), e0123295.

Funk, J. A.; Janech, M. G.; Dillon, J. C.; Bissler, J. J.; Siroky, B. J.; Bell, P. D., Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J Am Soc Nephrol 2014, 25 (6), 1187-97.

Neely, B. A.; Carlin, K. P.; Arthur, J. M.; McFee, W. E.; Janech, M. G., Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon. Front Endocrinol (Lausanne) 2013, 4, 132.

Bhensdadia, N. M.; Hunt, K. J.; Lopes-Virella, M. F.; Michael Tucker, J.; Mataria, M. R.; Alge, J. L.; Neely, B. A.; Janech, M. G.; Arthur, J. M.; Veterans Affairs Diabetes Trial study, g., Urine haptoglobin levels predict early renal functional decline in patients with type 2 diabetes. Kidney Int 2013, 83 (6), 1136-43.

Alge, J. L.; Karakala, N.; Neely, B. A.; Janech, M. G.; Tumlin, J. A.; Chawla, L. S.; Shaw, A. D.; Arthur, J. M.; Investigators, S. A., Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Clin J Am Soc Nephrol 2013, 8 (12), 2043-52.