Michael Janech
Associate Professor, SC Smart State Endowed Chair in Marine Environmental Health
Office Hours: By Appointment
Phone: 843.460.9788
E-mail: janechmg@cofc.edu
Education
B.S. – Biology, Oakland University
M.S. – Marine Biology, College of Charleston
Ph.D. – Molecular and Cellular Biology, Marine Biomedicine, Medical University of South Carolina
Post-Doc – Université de Montpellier II/IFREMER
Research Interests
Research in my laboratory focuses on mass spectrometry as an analytical tool to study comparative mechanisms underlying physiology and pathophysiology at the level of proteins. These studies are complemented by the use of proteomics, which is the study of many proteins at one time and their post-translational modifications. Interests include:
1) comparative proteomics and metaproteomics,
2) biomarkers of human and marine mammal disease,
3) mechanisms of osmoregulation and kidney function,
4) proteomics of algae.
My laboratory is funded by an NIH/NIDDK R15 to oversee the UROCUP program: Undergraduate Research Opportunity to explore the Composition of Urinary casts using Proteomics. UROCUP is a collaboration between CofC, Ochsner Medical Center – Nephrology, NIST, and University of Arkansas for Medical Sciences. Undergraduates utilize proteomics to discover proteins associated with urinary casts which assist in diagnosing and understanding mechanisms of acute kidney injury.
My laboratory is a lead participant in the NIST COMPARE project, which is a multi-institutional effort to characterize proteome differences between mammals to identify proteins that correlate with unique physiological adaptations.
Courses Taught
Publications
Select Publications
Julia Hopkins, Juan Carlos Q. Velez, John M. Arthur, Michael G. Janech. Are Undergraduates Familiar with Nephrology as a Medical Specialty? - A Single Site Survey of Undergraduate Students. Kidney360 Jun 2022, 10.34067/KID.0002472022; DOI: 10.34067/KID.0002472022
Hoard VF, Janech MG: Neurological deficits in stranded California sea lions. Vet Rec, 185: 301-303, 2019 10.1136/vr.l5400
Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D: Mitochondrial biogenesis induced by the beta2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney Int, 96: 656-673, 2019 10.1016/j.kint.2019.03.023
Srivastava P, Solanki AK, Arif E, Wolf BJ, Janech MG, Budisavljevic MN, Kwon SH, Nihalani D: Development of a novel cell-based assay to diagnose recurrent focal segmental glomerulosclerosis patients. Kidney Int, 95: 708-716, 2019 10.1016/j.kint.2018.10.030
Saito MA, Bertrand EM, Duffy ME, Gaylord DA, Held NA, Hervey WJt, Hettich RL, Jagtap PD, Janech MG, Kinkade DB, Leary DH, McIlvin MR, Moore EK, Morris RM, Neely BA, Nunn BL, Saunders JK, Shepherd AI, Symmonds NI, Walsh DA: Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing. J Proteome Res, 18: 1461-1476, 2019 10.1021/acs.jproteome.8b00761
Solanki AK, Arif E, Morinelli T, Wilson RC, Hardiman G, Deng P, Arthur JM, Velez JC, Nihalani D, Janech MG, Budisavljevic MN: A Novel CLCN5 Mutation Associated With Focal Segmental Glomerulosclerosis and Podocyte Injury. Kidney Int Rep, 3: 1443-1453, 2018 10.1016/j.ekir.2018.06.003
Neely, B. A.; Prager, K. C.; Bland, A. M.; Fontaine, C.; Gulland, F. M.; Janech, M. G., Proteomic Analysis of Urine from California Sea Lions ( Zalophus californianus): A Resource for Urinary Biomarker Discovery. J Proteome Res 2018.
Velez, J. C. Q.; Arif, E.; Rodgers, J.; Hicks, M. P.; Arthur, J. M.; Nihalani, D.; Bruner, E. T.; Budisavljevic, M. N.; Atkinson, C.; Fitzgibbon, W. R.; Janech, M. G., Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury. J Am Soc Nephrol 2017, 28 (7), 2119-2132.
Mock, T.; Otillar, R. P.; Strauss, J.; McMullan, M.; Paajanen, P.; Schmutz, J.; Salamov, A.; Sanges, R.; Toseland, A.; Ward, B. J.; Allen, A. E.; Dupont, C. L.; Frickenhaus, S.; Maumus, F.; Veluchamy, A.; Wu, T.; Barry, K. W.; Falciatore, A.; Ferrante, M. I.; Fortunato, A. E.; Glockner, G.; Gruber, A.; Hipkin, R.; Janech, M. G.; Kroth, P. G.; Leese, F.; Lindquist, E. A.; Lyon, B. R.; Martin, J.; Mayer, C.; Parker, M.; Quesneville, H.; Raymond, J. A.; Uhlig, C.; Valas, R. E.; Valentin, K. U.; Worden, A. Z.; Armbrust, E. V.; Clark, M. D.; Bowler, C.; Green, B. R.; Moulton, V.; van Oosterhout, C.; Grigoriev, I. V., Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus. Nature 2017, 541 (7638), 536-540.
Sobolesky, P. M.; Harrell, T. S.; Parry, C.; Venn-Watson, S.; Janech, M. G., Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids. Front Endocrinol (Lausanne) 2016, 7, 33.
Sobolesky, P.; Parry, C.; Boxall, B.; Wells, R.; Venn-Watson, S.; Janech, M. G., Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. Sci Rep 2016, 6, 33879.
Neely, B. A.; Soper, J. L.; Gulland, F. M.; Bell, P. D.; Kindy, M.; Arthur, J. M.; Janech, M. G., Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics 2015, 15 (23-24), 4051-63.
Velez, J. C.; Janech, M. G.; Hicks, M. P.; Morinelli, T. A.; Rodgers, J.; Self, S. E.; Arthur, J. M.; Fitzgibbon, W. R., Lack of renoprotective effect of chronic intravenous angiotensin-(1-7) or angiotensin-(2-10) in a rat model of focal segmental glomerulosclerosis. PLoS One 2014, 9 (10), e110083.
Neely, B. A.; Ferrante, J. A.; Chaves, J. M.; Soper, J. L.; Almeida, J. S.; Arthur, J. M.; Gulland, F. M.; Janech, M. G., Proeomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis. PLoS One 2014, 10 (4), e0123295.
Funk, J. A.; Janech, M. G.; Dillon, J. C.; Bissler, J. J.; Siroky, B. J.; Bell, P. D., Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J Am Soc Nephrol 2014, 25 (6), 1187-97.
Neely, B. A.; Carlin, K. P.; Arthur, J. M.; McFee, W. E.; Janech, M. G., Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon. Front Endocrinol (Lausanne) 2013, 4, 132.
Bhensdadia, N. M.; Hunt, K. J.; Lopes-Virella, M. F.; Michael Tucker, J.; Mataria, M. R.; Alge, J. L.; Neely, B. A.; Janech, M. G.; Arthur, J. M.; Veterans Affairs Diabetes Trial study, g., Urine haptoglobin levels predict early renal functional decline in patients with type 2 diabetes. Kidney Int 2013, 83 (6), 1136-43.
Alge, J. L.; Karakala, N.; Neely, B. A.; Janech, M. G.; Tumlin, J. A.; Chawla, L. S.; Shaw, A. D.; Arthur, J. M.; Investigators, S. A., Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Clin J Am Soc Nephrol 2013, 8 (12), 2043-52.